antinociceptive effects, acute toxicity and chemical composition of vitex agnus-castus essential oil
نویسندگان
چکیده
objective: vitex agnus-castus (vac) and its essential oil have been traditionally used to treat many conditions and symptoms such as premenstrual problems, mastalgia, inflammation, sexual dysfunction, and pain. in this study, the effects of essential oil extracted from vitex agnus-castus (eovac) leaves were investigated in three behavioral models of nociception in adult male wistar rats. materials and methods: chemical composition of eovac was analyzed using gas chromatography – mass spectrometry (gc-ms) and also its possible toxicity was determined in mice. analgesic effect of eovac was determined using tail immersion test, formalin test, and acetic acid-induced visceral pain in rats. results: eovac (s.c.) and morphine (i.p.) significantly (p<0.05) reduced pain responses in both formalin and tail immersion tests. in the study of evolved mechanisms, pretreatment with naloxone or atropine significantly (p <0.05) reversed the essential oil-induced analgesia in both formalin and tail immersion tests. moreover, eovac and piroxicam produced significant (p<0.05) inhibition in the acetic acid-induced writhing response.eovac did not show any mortality even at high dose (5 g/kg, p.o.) of administration in toxicity test. moreover, according to gc-ms results, major components of the eovac were α-pinene (14.83%), limonene (10.29%), β-caryophyllene (6.9%), sabinene (5.27%), and β-farnesene (5.9%). conclusions: these results suggest that endogenous opioidergic system as well as muscarinergic receptors of cholinergic system may be involve in the antinociceptive activity of vitex agnus-castus essential oil in these models of pain in rats.
منابع مشابه
Antinociceptive effects, acute toxicity and chemical composition of Vitex agnus-castus essential oil
Objective: Vitex agnus-castus (VAC) and its essential oil have been traditionally used to treat many conditions and symptoms such as premenstrual problems, mastalgia, inflammation, sexual dysfunction, and pain. In this study, the effects of essential oil extracted from Vitex agnus-castus (EOVAC) leaves were investigated in three behavioral models of nociception in adult male Wistar rats. Materi...
متن کاملAntinociceptive effects, acute toxicity and chemical composition of Vitex agnus-castus essential oil
OBJECTIVE Vitex agnus-castus (VAC) and its essential oil have been traditionally used to treat many conditions and symptoms such as premenstrual problems, mastalgia, inflammation, sexual dysfunction, and pain. In this study, the effects of essential oil extracted from Vitex agnus-castus (EOVAC) leaves were investigated in three behavioral models of nociception in adult male Wistar rats. MATER...
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Abnormal multiplication of oral bacteria causes dental caries and dental plaque. These diseases continue to be major public health concerns worldwide, mainly in developing countries. In this study, the chemical composition and antimicrobial activity of the essential oil of Vitex agnus-castus leaves (VAC‒EO) collected in the North of Brazil against a representative panel of cariogenic bacteria w...
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متن کاملAntibacterial activity and composition of essential oils from Pelargonium graveolens L'Her and Vitex agnus-castus L
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عنوان ژورنال:
avicenna journal of phytomedicineجلد ۵، شماره ۳، صفحات ۲۱۸-۲۳۰
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